CORDIS Project
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This project focuses on enhancing the generation of induced pluripotent stem cells by exploring the molecular mechanisms of cellular reprogramming. It aims to identify chromatin modifiers that can improve reprogramming efficiency, paving the way for advanced cell-based therapies.
Transcription factor-based reprogramming has enabled the generation of induced pluripotent stem cells (iPSCs). IPSCs can be used in disease modelling and derivation of rejection-free mature cell types for cell-replacement therapies.
Proof-of-principle studies show that a number of genetic, complex, and malignant diseases can benefit from such cell-based therapies.
Despite their immense potential, technical obstacles remain in the generation of iPSCs.
This project is aimed at generating tools to…
KOC UNIVERSITY
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