CORDIS Project
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This project investigates the transition of chronic myeloid leukaemia from its chronic phase to advanced stages using a novel mouse model. It aims to identify key molecules involved in this progression, which could lead to new therapeutic targets and prognostic indicators for patients.
The chronic phase of chronic myeloid leukaemia (CML) is characterized by the expression of the chimeric BCR-ABL gene, extended survival, and profligate growth of maturing granulocyte stemline.
It provided the rationale for producing first imatinib and then a series of small molecules designed to inhibit the tyrosine kinase activity of the BCR-ABL oncoprotein, all of which can induce complete cytogenetic remissions in the majority of patients with CML in the chronic phase (CP).
Selective inhibiti…
LUDWIG BOLTZMANN GESELLSCHAFT GMBH
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