CORDIS Project
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The CloSed project aims to improve sedation practices in pediatric intensive care by developing a safe, age-appropriate formulation of clonidine. It includes a clinical trial to compare clonidine with midazolam, addressing a critical need for effective sedation in critically ill children.
The majority of critically ill children admitted to Paediatric Intensive Care Units (PICU) will require sedationand analgesia which is commonly achieved with a combination of an benzodiazepine and an opioid.
However,these agents have a significant side-effect profile, including tolerance, withdrawal and respiratory/circulatorydepression.
Clonidine is commonly used for sedation in PICU and recommended by guidelines in variouscountries although there is a lack of evidence regarding it safety and e…
UNIVERSITATSKLINIKUM ERLANGEN
Partner organizations (coordinator is shown above), with normalized type and CORDIS activity type. Guests see up to 4 partners.
United Kingdom, London
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
United Kingdom, London
Type: Company (for-profit)
Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
Netherlands, Rotterdam
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
Italy, Valenzano Bari
Type: Research institute
Activity type: Research Organisations
SME: No
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