CORDIS Project
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This project explores the molecular mechanisms of chloride handling in the kidneys, particularly focusing on the ClC-kb channel and its role in hypertension. It aims to provide insights into how chloride transport affects blood pressure regulation and potential treatment avenues.
Hypertension, or elevated arterial blood pressure, is a significant global health concern. A major cause of hypertension is the abnormality in salt (NaCl) handling in distal nephron segments within kidney.
Although there has been long a debate with regard to the relative importance of Na+ vs.
Cl- in inducing salt-sensitive hypertension, previous research demonstrated that excess intake of Cl- could lead to severe salt-sensitive hypertension.
Thus, better understanding on molecular mechanisms…
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
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