CORDIS Project
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This project investigates the molecular mechanisms of circadian rhythms by analyzing protein and phosphoprotein oscillations in mouse tissues using advanced mass spectrometry and bioinformatics. It aims to create a comprehensive database of circadian profiles and identify novel regulators of circadian activity and thei…
The circadian clock is an endogenous oscillator that drives daily rhythms in physiology and behavior.
The mechanism underlying circadian timekeeping is cell-autonomous and oscillations are generated by interconnecting transcriptional and translational feedback loops.
To date large-scale approaches to study molecular circadian rhythms have been limited to the analysis of the transcriptome (mRNA).
However, the “true” mediators of cellular functions are proteins.
Recent advances in mass spectrometr…
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
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