CORDIS Project
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This project investigates how DNA damage leads to mutations that accumulate over time, particularly in non-dividing cells like neurons. By developing a new technology to detect mutations in single cells, the research aims to uncover the mechanisms behind these 'clock' mutations and their implications for aging and canc…
DNA damage contributes to the ageing of tissues and causes mutations that drive cancer.
However, the molecular mechanisms underlying many mutational processes are not understood, and neither is how much they contribute to disease.
With a powerful new technology, I propose to close these major gaps for common ?clock? mutations of unknown origin.The recent genome sequencing revolution has revealed unexpected diversity in mutational patterns.
One pattern in particular is intriguing as it behaves as…
KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW
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