CORDIS Project
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This project focuses on developing cultured liver organoids to study liver diseases and potential treatments for inherited cholestatic disorders. It aims to create functional liver models using stem cells and 3-D scaffolds to address the shortage of donor organs.
Bile synthesis and secretion are crucial to liver function and involve multiple proteins.
Disorders due to defects in this process (Inherited Cholestatic Disorders, ICDs) lead to progressive liver disease.
Many ICD patients do not respond to medical treatment and need liver transplantation (LT).
Although ICDs are rare, multifactorial cholestatic diseases are common and many patients will benefit from ICD research.There is acute shortage of liver donors. 10% of patients die while waiting on the l…
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