CORDIS Project
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This project aims to identify germline risk factors for chronic lymphocytic leukemia (CLL) by analyzing genetic data from patients. It seeks to understand the early genetic events leading to B-cell malignancy, enhancing knowledge of CLL pathogenesis.
Chronic lymphocytic leukemia (CLL) is a cancer of B-lymphocytes, which expands in the bone marrow, lymph nodes, spleen and blood.
While many genes have been implicated in CLL development through sequencing the genome of tumor cells, they do not completely explain the pathogenesis of the disease, nor define the early events that lead the B-cells to proliferate and become cancerous, accumulating the different types of somatic mutations of CLL.
Most sequencing studies have focused only on discovery…
FUNDACIO CENTRE DE REGULACIO GENOMICA
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