CORDIS Project
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This project investigates the CLEAR gene network that regulates lysosomal function and cellular clearance. It aims to understand its mechanisms and develop therapeutic strategies for neurodegenerative diseases, utilizing various biological and genetic approaches.
Cellular clearance is a fundamental process required by all cells in all species.
Important physiological processes, such as aging, and pathological mechanisms, such as neurodegeneration, are strictly dependent on cellular clearance.
In eukaryotes, most of the cellular clearing processes occur in a specialized organelle, the lysosome.
This project is based on a recent discovery, made in our laboratory, of a gene network, which we have named CLEAR, that controls lysosomal biogenesis and function…
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