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CisTune investigates how gene regulation in multicellular organisms is influenced by various signals, focusing on the Xist locus responsible for X-chromosome inactivation in females. The project aims to understand the mechanisms behind cis-regulatory landscapes that control gene activity during development using advanc…
Development of multicellular organisms relies on differential gene activation in a single genome.
In response to multiple quantitative signals, cell-type specific transcriptional programs are established that determine cell identify.
Their perturbation can result in pathologies such as cancer.
Large cis-regulatory landscapes integrate information on cell state, space and time to precisely tune the activity of developmental genes.
How cis-regulatory landscapes decode multiple quantitative signals…
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
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