CORDIS Project
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This project investigates how cancer cells can switch between different states, impacting their growth and resistance to treatment. By understanding the genetic enhancers involved in this process, the project aims to create synthetic enhancers to monitor and control these transitions in real time.
Cell-state switching in cancer allows cells to transition from a proliferative to an invasive and drug-resistant phenotype.
This plasticity plays an important role in cancer progression and tumour heterogeneity.
We have made a striking observation that cancer cells of different origin can switch to a common survival state.
During this epigenomic reprogramming, cancer cells re-activate genomic enhancers from specific regulatory programs, such as wound repair and epithelial-to-mesenchymal transiti…
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