CORDIS Project
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This project investigates the role of the CYLD enzyme in Chronic Lymphocytic Leukaemia (CLL) by creating transgenic mouse models. It aims to clarify CYLD's function in B-lymphocyte development and its implications for CLL, potentially identifying new biomarkers and therapeutic targets.
This project will investigate the role of CYLD in Chronic Lymphocytic Leukaemia (CLL). CYLD is a deubiquinating enzyme acting as a tumour suppressor in numerous tumours. CLL is characterized by the accumulation of B-lymphocytes.
It affects mostly the elder and has a high incidence rate in Europe.
Recent data from CYLD knockout murine models indicate a link between CYLD and CLL, however the approach used for generation of these mice led to contrasting results.At the core of this interdisciplinary…
UNIVERSITA VITA-SALUTE SAN RAFFAELE
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