CORDIS Project
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CIRCLE focuses on developing synthetic circular RNAs to modulate protein expression in endothelial cells, aiming to reverse organ failure caused by sepsis. By enhancing the stability and delivery of these RNA-based drugs, the project seeks to create new therapeutic strategies for treating sepsis-related complications i…
Reversing organ failure, a leading cause of death in sepsis, requires specific modulation of biological pathways in endothelial cells, which is currently not possible with the existing drugs available.
Employing RNA-based drugs to control protein expression could offer a novel therapeutic strategy in the fight against sepsis.Circular RNAs (circRNAs) are a new class of non-coding RNAs with a unique closed-loop structure that could help address the current limitations of the RNA drugs in the disea…
UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK
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