CORDIS Project
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This project explores the role of circadian clock genes in the secretion of insulin and glucagon in diabetes. By manipulating these genes in mouse models, it aims to understand how disruptions in circadian rhythms contribute to metabolic disorders.
Diabetes Mellitus is considered a bihormonal disorder that involves insulin resistance and insulin deficiency as well as relative or absolute high levels of glucagon.
Recently, a strong association has been found between disturbances in circadian rhythms and metabolic disorders such as Diabetes Mellitus and Obesity.
In this proposal we will use in vitro techniques to knockdown several clock genes in mouse pancreatic islets, MIN6 and alpha-TC1-9 cell lines to establish the role of clock genes in…
UNIVERSIDAD MIGUEL HERNANDEZ DE ELCHE
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