CORDIS Project
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This project focuses on understanding chromosomal instability in gastric cancer, which contributes to poor prognosis and immune response issues. It aims to develop advanced single cell sequencing methods to investigate the mechanisms driving this instability and its effects on the tumor microenvironment.
Chromosomal instability (CIN) is a main cause of tumor heterogeneity, tumor evolution and therapy resistance of cancers.
Chromosomally instable gastric cancer (CIN-gastric cancer) accounts for 50-70% of gastric tumors and is the poorest prognosis tumor subtype with the most suppressed tumor immune microenvironment.
However, it is not understood how CIN contributes to poor prognosis and edits the tumor immune response of CIN-gastric cancer, due to a lack of assays investigating native CIN-driving…
ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
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