CORDIS Project
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This project investigates the roles of cilia proteins in cell division, aiming to uncover their functions beyond cilia-related processes. By utilizing high content screening and zebrafish models, it seeks to understand how these proteins contribute to kidney cyst formation and other pathologies.
Cilia proteins, including proteins of the intraflagellar transport machinery (IFT) were initially identified for their link to polycystic kidney disease but were also described as potential tumor suppressor.
This suggests that common cellular pathways, which have yet to be characterized, might contribute to both benign cyst formation and cancer.
Cystogenesis has long been associated exclusively with cilia dysfunction.
However, our recent finding of IFT88 functioning in spindle orientation during…
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
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