CORDIS Project
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This project investigates the intraflagellar transport mechanism essential for cilia assembly and function. By analyzing the structure and regulation of the IFT complex, it aims to enhance understanding of ciliogenesis and its implications for health.
The cilium is an organelle that protrudes from the cell body and is responsible for the motility of unicellular organisms and of vertebrate cell types such as sperm cells.
In addition, most vertebrate cells have primary non-motile cilia important for sensory reception and signalling.
The assembly and function of cilia rely on intraflagellar transport (IFT), the bi-directional movement of macromolecules between the cell body and the cilium.
As cilia do not contain ribosomes, IFT is required to mo…
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
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