CORDIS Project
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This research investigates how mechanical loading influences the behavior of mesenchymal stem cells in bone formation to combat osteoporosis. By studying primary cilia as sensors, the project aims to develop new therapies that enhance bone regeneration and reduce the risk of fractures.
Every 30 seconds a person suffers an osteoporosis-related bone fracture in the EU, resulting in significant morbidity, mortality, and health-care costs estimated at €36billion annually.
Current therapeutics target bone resorbing osteoclasts, but these are associated with severe side effects.
Osteoporosis arises when mesenchymal stem cells (MSC) fail to produce sufficient numbers of bone forming osteoblasts. A key regulator of MSC behaviour is physical loading, yet the mechanisms by which MSCs se…
THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN
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Ireland, Limerick
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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