CORDIS Project
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The ChRONAM-H project investigates the role of Chromatin Factors in blood cell development and cancer. By utilizing advanced profiling techniques, it aims to uncover the mechanisms behind hematopoiesis and potential therapeutic targets for leukemia.
Chromatin Factors (CFs) comprise a diverse family of proteins that elicit key regulatory epigenetic activities during the regulation of cellular fates.
Although this heterogeneous group has been traditionally considered a static toolkit of epigenetic enzymes deployed to lineage-specific loci under the control of Transcription Factors (TFs), recent works have shown that CFs are crucial determinants of developmental lineage decisions that assemble into dynamic chromatin regulatory complexes with e…
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