CORDIS Project
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This research examines DNA recombination to understand its role in preventing cancer and developmental defects. By studying DNA repair mechanisms in normal and tumor cells, the project aims to uncover variations in genomic rearrangements and improve cancer therapy approaches.
Accurate DNA recombination is critical for preventing tumorigenesis and developmental defects.
In normal cells, the DNA damage response helps prevent the propagation cells with aberrant chromosome content.
It is known that DNA repair often compromised in tumor cells, but much remains to be discovered about its regulation on the molecular level.
For instance, how much cell-to-cell or patient-to-patient variation is there in the type and frequency of DNA rearrangements?
What puts certain genomic a…
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