CORDIS Project
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This project investigates the mechanisms of chromosome segregation during cell division, focusing on the roles of centromeres and inner centromeres in ensuring accurate chromosome attachment and cohesion. It employs advanced structural and biochemical techniques to understand how these processes prevent chromosomal err…
Accurate chromosome segregation during cell division requires bipolar attachment of sister-chromatids to microtubules emanating from opposite spindle poles and maintenance of sister-chromatid cohesion until all chromosomes achieve bi-orientation.
Two chromosomal sites regulate these processes: centromeres, the microtubule attachment sites defined by the enrichment of CENP-A nucleosomes, and the inner centromere, a region between the sister-chromatids that recruits enzymatic activities (kinases,…
LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
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United Kingdom, Edinburgh
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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