CORDIS Project
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This project investigates common fragile sites in human DNA, which are prone to breaks and linked to cancer. Using advanced genome editing techniques, it aims to understand their physiological roles and the impact of cellular processes on their stability.
Cancer and other diseases are driven by genomic alterations initiated by DNA breaks.
Within our genomes, some regions are particularly prone to breakage, and these are known as common fragile sites (CFSs). CFSs are present in every person and are frequently sites of oncogenic chromosomal rearrangements.
Intriguingly, despite their fragility, many CFSs are well conserved through evolution, suggesting that these regions have important physiological functions that remain elusive.
My previous backgr…
AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
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Denmark, Kobenhavn
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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