CORDIS Project
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This project focuses on understanding how chromatin structure affects DNA repair and gene regulation, with implications for cancer and aging. It combines genetic analysis and mouse models to explore how modifications in chromatin can influence cellular responses to DNA damage.
With the availability of the essentially complete sequence of the human genome, as well as a rapid development of massive sequencing techniques, the research efforts to understand genetics and disease from a cis standpoint will soon reach an endpoint.
However, our emerging knowledge of gene regulation networks reveals that epigenetic regulation of the hereditary information plays crucial roles in various biological events through its influence on processes such as transcription, DNA replication…
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