CORDIS Project
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This research project aims to uncover the mechanisms of histone deposition during DNA replication, focusing on how epigenetic information is preserved. By using advanced imaging and biochemical techniques, it seeks to understand the dynamics of chromosome assembly and its implications for cell identity.
The gene expression patterns that define specific cell types are determined in part by epigenetic information encoded in histone marks that guide chromatin organization.
During chromosome duplication, new histones lacking this information must be deposited to support the doubling of chromatin.
However, the molecular mechanism of histone deposition and the coordination pathways that ensure epigenetic information is transmitted remain unknown.
Determining the mechanics of chromosome assembly promi…
TECHNISCHE UNIVERSITAET MUENCHEN
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