CORDIS Project
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This project investigates the active role of chromosomes during cell division, focusing on how their structure affects the accuracy of mitosis. By employing advanced imaging and protein inactivation techniques, it aims to redefine our understanding of chromosome behavior and its implications for cellular development.
Genome stability relies on accurate partition of the genome during nuclear division.
Proper mitosis, in turn, depends on changes in chromosome organization, such as chromosome condensation and sister chromatid cohesion.
Despite the importance of these structural changes, chromatin itself has been long assumed to play a rather passive role during mitosis and chromosomes are usually compared to a “corpse at a funeral: they provide the reason for the proceedings but do not take an active part in th…
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