CORDIS Project
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This project investigates how gene expression regulation and chromatin organization influence cell differentiation in C. elegans. It aims to identify the signals and molecules responsible for anchoring heterochromatin at the nuclear periphery and assess the impact of chromatin compartmentalization on tissue differentia…
Co-ordinating the patterns of gene expression that drive the development of a complex organism requires multiple layers of regulation, extending from sequence-based DNA-protein interactions to higher-order architecture of the genome.The spatial organization of chromatin within the nucleus is thought to reflect a functional compartmentalization that mirrors changes in cell fate.
Recently, the signals and proteins involved in the topological organization of heterochromatin in complex organisms sta…
FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH FONDATION
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