CORDIS Project
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This project investigates how proteins organize chromosomes into three-dimensional structures essential for gene regulation. By using advanced single molecule techniques, it aims to uncover the molecular mechanisms behind chromosomal organization and the formation of topologically associated domains.
The three-dimensional organization of chromosomes is necessary for hereditary fidelity and gene regulation.
Recent studies have found that eukaryotic interphase chromosomes are spatially organized in compartments, chiefly topologically associated domains (TADs), in a hierarchical order of nested chromatin loops, coining the term “chromosome folding”. TADs are clusters of genes and regulatory elements that are confined to their genomic compartment by spatially constricting their accessible range…
LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
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