CORDIS Project
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This project investigates the dynamics of X chromosome inactivation in female mammals, focusing on the role of epigenetic memory and chromatin changes. By combining various experimental techniques, it aims to uncover the mechanisms behind transcriptional repression and its implications for development and disease.
Developmental progression is linked to accumulation of epigenetic memory mainly in the form of chemical modifications of the chromatin.
However, the dynamics of this process as well as its functional relevance remains unclear.
One of the most striking examples of transcriptional regulation by epigenetic processes is random X chromosome inactivation (XCI) in female mammalian embryos, which evolved to compensate between XX and XY individuals.
This process is strictly dependent on coating of one X…
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