CORDIS Project
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This project focuses on understanding the genetic complexities of leukemia to develop targeted therapies. By utilizing advanced mouse models and RNA interference technologies, it aims to identify chromatin regulators that could serve as effective therapeutic targets for treating various leukemia subtypes.
Recent advances in genome sequencing illustrate the complexity, heterogeneity and plasticity of cancer genomes.
In leukemia - a group of blood cancers affecting 300,000 new patients every year – we know over 100 driver mutations.
This genetic complexity poses a daunting challenge for the development of targeted therapies and highlights the urgent need for evaluating them in combination.
One gene class that has recently emerged as highly promising target space are chromatin regulators, which main…
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