CORDIS Project
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This project investigates how epigenetic mechanisms influence gene expression in cells, particularly focusing on histone modifications. Using budding yeast as a model, it aims to understand the dynamic relationship between chromatin states and transcriptional activity through advanced experimental techniques.
Epigenetic mechanisms play an important role in regulating and maintaining the functionality of cells and have been implicated in a wide range of human diseases.
Histone proteins that form the protein core of nucleosomes are subject to a bewildering array of covalent and structural modifications, which can repress, permit, or promote transcription.
These modifications can be added and removed by specialized complexes that are recruited by other covalent modifications, by transcription factors, o…
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