CORDIS Project
Funding breakdown and partner intelligence are Premium
Sign in and upgrade to Premium for EU contribution totals, consortium analytics, OpenAlex research context, and AI summaries. · 0 consortium intelligence fields visible of 1
Start free • Cancel anytime • 14-day refund guarantee
This project investigates the role of the ALC1 protein in DNA damage repair and chromatin remodeling. By generating mouse models, it aims to clarify ALC1's function in response to DNA damage and its implications for cancer and neurodegenerative diseases.
The genome is continuously exposed to DNA damaging insults that induce a wide variety of lesions.
For a proper DNA damage signalling and repair, chromatin remodelling is most likely a prerequisite.
Poly(ADP-ribose) (PAR) is known to induce chromatin relaxation at DNA damage sites but how this is achieved remains unclear.
My host lab recently identified ALC1 (Amplified in Liver Cancer 1) that binds to PAR via a C-terminal Macro domain and catalyzes PARP1-stimulated nucleosome sliding by an N-term…
CANCER RESEARCH UK LBG
Partner organizations (coordinator is shown above), with normalized type and CORDIS activity type. Guests see up to 4 partners.
Similar projects, consortium collaboration history, frequent partners, and OpenAlex research context.
Guests see up to 5 EuroSciVoc fields.
Guests see up to 5 topics.
