CORDIS Project
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This project enhances drug behavior studies using zebrafish as a model to explore absorption, distribution, metabolism, and excretion. It focuses on developing advanced analytical techniques to measure drug uptake in the brain, addressing challenges posed by the blood-brain barrier.
ADME (Absorption, Distribution, Metabolism and Excretion) studies focus on the examination and prediction of drug behavior in the human body.
Zebrafish present a good in vivo model for this purpose since they comply with the 3R principle of humane animal research (Replacement, Reduction and Refinement).
The research group of Prof.
Deirdre Cabooter recently developed a novel sample preparation and analytical method to accurately measure the whole-body uptake of drugs in zebrafish.
The next step i…
KATHOLIEKE UNIVERSITEIT LEUVEN
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