CORDIS Project
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This project investigates how histone chaperones manage the organization of the genome by regulating histone variants. It aims to understand the dynamic adaptability of these proteins during various cellular processes, including differentiation and repair, using advanced imaging and mass spectrometry techniques in cell…
A central question in chromatin biology is how to organize the genome and mark specific regions with histone variants.
Understanding how to establish and maintain, but also change chromatin states is a fundamental challenge.
Histone chaperones, escort factors that regulate the supply, loading, and degradation of histone variants, are key in their placement at specific chromatin landmarks and bridge organization from nucleosomes to higher order structures. A series of studies have underlined chap…
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