CORDIS Project
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This project explores how transcription factors interact with chromatin to regulate gene expression in eukaryotes, particularly within the circadian system. By using various model organisms, it aims to uncover the fundamental mechanisms of gene regulation and the role of chromatin in these processes.
Transcription factors (TFs) distinctly mark regions of the genome for expression and are the pillars of cell identity.
Yet, even at the basic level of DNA recognition by TFs, we know very little about how this is achieved.
In eukaryotes, all DNA-templated processes occur in chromatin; however, most studies elucidating the molecular mechanisms of transcription have been performed on histone-free DNA.
In the proposed project, we will use TFs as centerpieces to understand how, in the circadian syst…
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