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The CHROMABOLISM project investigates the role of metabolites and metabolic enzymes in gene regulation and cellular identity within the nucleus. By profiling these components in leukemia cells, the project aims to uncover their impact on chromatin structure and gene expression, potentially identifying new targets for c…
Epigenetics research has revealed that in the cell’s nucleus all kinds of biomolecules–DNA, RNAs, proteins, protein posttranslational modifications–are highly compartmentalized to occupy distinct chromatin territories and genomic loci, thereby contributing to gene regulation and cell identity.
In contrast, small molecules and cellular metabolites are generally considered to passively enter the nucleus from the cytoplasm and to lack distinct subnuclear localization.
The CHROMABOLISM proposal chal…
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