CORDIS Project
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This project focuses on using engineered scaffolds and small interfering RNA to regenerate cartilage in osteoarthritis. It aims to develop a delivery platform that bypasses traditional cell delivery limitations, targeting connexin 43 to restore healthy cartilage metabolism.
Regenerative medicine strategies using engineered scaffolds have shown promise to regenerate cartilage in degenerative conditions (e.g. osteoarthritis, OA).
However, it is clear further cues are required to control repair in situ.
Small interfering (si)RNA can control protein expression but current cell delivery methods require endosome escape, limiting efficacy.
Cell delivery of small molecules through connexons (Cx) bypasses the endosome and can be achieved by gap junction formation between c…
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