CORDIS Project
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This project focuses on cholangiocarcinoma, a type of bile duct cancer, exploring its molecular mechanisms and developing potential therapeutic targets. It utilizes advanced mouse models and screening technologies to understand cancer progression and the role of the gut microbiome.
Genetic heterogeneity and complexity are hallmarks of metastatic solid tumors and therapy resistance inevitably develops upon treatment with cytotoxic drugs or molecular targeted therapies.
Cholangiocarcinoma (CCC, or bile duct cancer) represents the second most frequent primary liver tumor and has emerged as a health problem with sharply increasing incidence rates, in particular of intrahepatic CCC (ICC).
The reason for increased CCC incidence remains unclear, but influences of western lifestyl…
EBERHARD KARLS UNIVERSITAET TUEBINGEN
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