CORDIS Project
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This project aims to develop a new method for producing enantiomerically pure molecules by manipulating the stability of racemic compounds under non-equilibrium conditions. The approach seeks to convert thermodynamically stable mixtures into desired single-handed forms, which is crucial for pharmaceuticals and bioactiv…
The molecular building blocks of life are of only one handedness.
Consequently, pharmaceuticals and other bioactive molecules also need to be of one handedness.
When such enantiomers crystallize in separate crystals, isolation of the desired handedness is relatively straightforward.
Unfortunately, most enantiomers (90-95%) are thermodynamically more stable as racemic compounds with both enantiomers in the crystallographic unit cell, which impedes any such separations.
There are currently no meth…
STICHTING NEDERLANDSE WETENSCHAPPELIJK ONDERZOEK INSTITUTEN
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