CORDIS Project
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This project aims to explore clonal hematopoiesis, particularly its role in cancer progression and risk of therapy-related myeloid neoplasms. By developing tools for early detection and understanding the molecular mechanisms involved, it seeks to improve cancer patient management.
Clonal hematopoiesis (CH) is the expansion of somatically mutated hematopoietic stem cells.
Clonal hematopoiesis of indeterminate potential (CHIP) occurs when CH is driven by mutations in myeloid driver genes in individuals without hematologic disorders. CHIP increases the risk of hematological malignancies and chronic inflammatory diseases. CHIP is also associated with a higher incidence of non-hematological malignancies, such as lung cancer.
These associations underline the importance of CHIP…
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