CORDIS Project
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This project investigates the role of the cell adhesion molecule Cdon in the development of the eye in zebrafish. It aims to understand how Cdon interacts with Hedgehog signaling to influence eye patterning and may contribute to advancements in regenerative medicine for congenital eye disorders.
Patterning of the vertebrate optic vesicle into proximal/optic stalk and distal/neural retina involves midline-derived Hh signalling, which promotes stalk specification.
At the neural retina/optic stalk border, the cell adhesion molecule Cdon binds Hh, acting as a decoy receptor to protect the neural retina from Hh activity.
How Cdon controls Hh dispersion, what is the destiny of the Hh protein accumulated at the neural retina/optic stalk boundary, whether Cdon participates in the release of Hh…
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