CORDIS Project
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CHEMTUBIO focuses on developing innovative methods to detect and study enzymes that remove specific protein modifications, particularly in the context of cancer and neurological disorders. The project aims to create tools for in situ analysis of these enzymes, enhancing our understanding of their roles and potential as…
Erasers of protein post-translational modifications are ubiquitous regulatory enzymes that control cellular function and are targeted for the treatment of disease.
One key example are erasers of histone acetylation, where inhibitors have reached the clinic as cancer chemotherapy.
Currently, however, multiple other erasers lack tools of study to determine their relevance and generate clinical candidate molecules.
One main reason for this limitation is that erasers display multivalent substrate re…
FUNDACIO INSTITUT DE BIOENGINYERIA DE CATALUNYA
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