CORDIS Project
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The chemREPEAT project aims to investigate the structure and dynamics of Low-Complexity Regions in proteins, particularly homorepeats. By using isotopically labeled amino acids, the research seeks to understand the link between protein structure and diseases like Huntington's.
Proteins hosting regions highly enriched in one or few amino acids, the so-called Low-Complexity Regions (LCR), are very common in eukaryotes and play crucial roles in biology.
Homorepeats, a subfamily of LCR that present stretches of the same amino acid, perform very specialized functions facilitated by the localized enrichment of the same physicochemical property.
In contrast, numerous severe pathologies have been associated to abnormally long repetitions.
Despite the relevance of homorepeats,…
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
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