CORDIS Project
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This project focuses on developing new protease inhibitors targeting flaviviruses by creating a fast and versatile synthetic methodology. It aims to produce a range of compounds with improved potency and biopharmaceutical properties for better management of flavivirus infections.
Protease inhibitors can potently block the viral replication cycle.
In the context of flaviviruses, NS2B-NS3 protease is a promising viral drug target because of its well conserved backbone among flaviviral species, opening the perspective of developing pan-anti-flaviviral NS2B-NS3 inhibitors.
All reported NS2B-NS3 inhibitors, however, suffer from low potency and/or poor biopharmaceutical properties.
Structural optimization has proven to be slow and challenging, in part because synthetic methodo…
UNIVERSITEIT ANTWERPEN
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Belgium, Leuven
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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