CORDIS Project
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This project focuses on developing chemical probes to study protein AMPylation, a process that modifies proteins and influences cell signaling. By analyzing AMPylation during bacterial infections, the project aims to uncover new biological mechanisms that could lead to innovative antibiotic therapies.
In 2009 protein AMPylation, the reversible post-translational adenylation of target proteins with adenosine monophosphate (AMP), was first revealed as a novel mechanism for pathogenic bacteria to target and disrupt interactions of host GTPases with their cognate binding partners.
Furthermore, there is growing evidence that AMPylation also operates as a general intracellular signaling mechanism in normal cell function.
This novel post-translational modification is catalyzed by AMP transferases co…
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