CORDIS Project
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This project investigates the mechanisms that inactivate the DNA damage checkpoint, which is crucial for maintaining genome integrity. By identifying novel Checkpoint Inactivating Factors and their roles in the cellular response to DNA damage, the research aims to provide insights for developing new cancer therapies.
Eukaryotic cells need to preserve the integrity of their genomes.
Conditions resulting in increased genome instability, defined as the generation and amplification of mutations and chromosomal aberrations, are associated with cancer predisposition and human pathologies.
The DNA damage checkpoint acts as a surveillance mechanism that safeguards genome integrity in response to genotoxic insults.
While the processes leading to DNA damage checkpoint activation have been extensively studied, little i…
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