CORDIS Project
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This project focuses on understanding the physiological roles of specific phosphoinositide 3-kinases, particularly class II PI3Ks, in cellular processes like membrane trafficking and signaling. By utilizing innovative mouse models, it aims to explore their potential as drug targets in cancer treatment.
Phosphoinositide 3-kinases (PI3Ks) are lipid kinases that generate intracellular second messengers in signal transduction and membrane trafficking pathways and are important drug targets.
This proposal seeks to delineate the roles and mechanism of action of a group of PI3Ks which have remained enigmatic ever since their discovery over a decade ago.The PI3K family comprises eight members in three subclasses.
Class I PI3Ks signal downstream of growth factor and G protein-coupled receptors, are amo…
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