CORDIS Project
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This project investigates the molecular mechanisms behind Fragile-X mental retardation syndrome by analyzing synapse composition in a mouse model. It aims to identify dysregulated mRNAs and proteins, focusing on the role of FMRP in mRNA metabolism and synaptic function, which could inform future therapeutic strategies.
Fragile-X mental retardation syndrome (FXS) is caused by mutations in the Fmr1 gene that codes for the FMRP protein. FMRP is an RNA binding protein involved in mRNA metabolism.
The translational dysregulation of a subset of FMRP target mRNAs is probably the major contribution to FXS. A hallmark of the FXS phenotype is the elevated spine density with immature morphology.
We aim to understand the causes of this spine dysmorphogenesis by unraveling the molecular composition of synapses in a mouse m…
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