CORDIS Project
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This project investigates the role of the BCA2 protein in inhibiting HIV-1 virus production through both tetherin-dependent and independent mechanisms. By understanding BCA2's molecular interactions, the research aims to identify new targets for antiretroviral therapies to control HIV-1 infection.
BCA2 (Breast Cancer-Associated gene 2, also known as RNF115, ZNF364 or Rabring7) is a cytoplasmic RING-finger E3 ubiquitin ligase that is upregulated in most breast cancer cell lines in response to estrogen. A recent study showed that BCA2 interacts with the cytoplasmic domain of tetherin/BST2 to promote the internalization and degradation of tethered HIV-1 particles, and that the E3 ligase activity of BCA2 is dispensable to enhance the tetherin-mediated restriction of HIV-1.
Therefore, BCA2 wou…
MEDIZINISCHE HOCHSCHULE HANNOVER
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