CORDIS Project
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This project investigates the role of a specific enzyme, p110beta, in cancer signaling using genetically modified mouse models. It aims to clarify how different isoforms of phosphoinositide 3-kinases contribute to pancreatic cancer, with the goal of improving therapeutic strategies for this lethal disease.
PI 3-kinases (PI3Ks) are key signal transduction enzymes which are generally considered to be excellent new targets for therapeutic interference.
Mammals have multiple PI3K isoforms.During my UK post-doctoral training funded by EIF, I have created and characterized new mouse models targeting one isoform of PI3K, p110beta, which physiological role was unknown.
Isoform-specificity of p110beta in cell signalling, and in physiology, in particular in angiogenesis, was investigated using these gene-ta…
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
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