CORDIS Project
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This project investigates the role of the E3 ubiquitin ligase Arkadia in the TGF-beta signaling pathway, focusing on its function in degrading transcriptional repressors linked to tumorigenesis. By studying Arkadia's mechanisms and effects on cancer cell behavior, the project aims to identify its potential as a novel t…
Deregulated signalling by transforming growth factor beta (TGF-beta) plays a critical role in tumorigenesis in humans, acting as a tumour suppressor at early stages, but as a tumour promoter at late stages.
To be able to diagnose and treat human cancer, it is essential that we understand these processes at the molecular level.
Recent work in the host lab has established that the E3 ubiquitin ligase, Arkadia is an essential component of the branch of the TGF-beta/Smad pathway that is mediated via…
CANCER RESEARCH UK LBG
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